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Article

Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2006

Geoffrey Rhonda, Jia Shuang, Kwitek Anne E, Woodliff Jeffrey, Ghosh Soumitra, Lernmark Ake, Wang Xujing, Hessner Martin J

Abstract excerpt

Human type 1 diabetes mellitus (T1DM) arises through autoimmune destruction of pancreatic beta cells and is modeled in many respects by the lymphopenic and spontaneously diabetic BioBreeding (BB) DRlyp/lyp rat. Previously, preonset expression profiling of whole DRlyp/lyp pancreatic lymph nodes (PLN) revealed innate immune activity, specifically that of mast cells and eosinophils. Furthermore, we observed that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 17082646
DOI: 10.4049/jimmunol.177.10.7275

Genes

PLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.PMID 17082646Read ↗

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