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Article

Early deficits in insulin secretion, beta cell mass and islet blood perfusion precede onset of autoimmune type 1 diabetes in BioBreeding rats.

Diabetologia - 1 Apr 2018

Medina Anya, Parween Saba, Ullsten Sara, Vishnu Neelanjan, Siu Yuk Ting, Quach My, Bennet Hedvig, Balhuizen Alexander, Åkesson Lina, Wierup Nils, Carlsson Per Ola, Ahlgren Ulf, Lernmark Åke, Fex Malin

Abstract excerpt

AIMS/HYPOTHESIS: Genetic studies show coupling of genes affecting beta cell function to type 1 diabetes, but hitherto no studies on whether beta cell dysfunction could precede insulitis and clinical onset of type 1 diabetes are available. METHODS: We used 40-day-old BioBreeding (BB) DRLyp/Lyp rats (a model of spontaneous autoimmune type 1 diabetes) and diabetes-resistant DRLyp/+ and DR+/+ littermates (controls)...

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Identifiers

PMID: 29209740
DOI: 10.1007/s00125-017-4512-z
PMCID: PMC6448977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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