Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.

doi:10.1097/00006676-200001000-00007

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Article

Rel B is an early marker of autoimmune islet inflammation in the biobreeding (BB) rat.

Pancreas - 1 Jan 2000

Bieg S, Simonson W, Ellefsen K, Lernmark A

Abstract excerpt

Because the development of insulitis and diabetes is predictable in Lyp/Lyp congenic BB rats, we have characterized early islet inflammation in these rats to determine the cell subsets involved in the onset of autoimmune insulitis. Pancreas sections from prediabetic Lyp/Lyp, Lyp/+ and +/+ rats were analyzed by immunohistochemistry. We found W3/25+ cells in the exo- and endocrine tissue from all three genotypes,...

Topics

Age Factors
Animals
Animals, Congenic
Antigen Presentation
Autoimmune Diseases
Biomarkers
Dendritic Cells
Diabetes Mellitus, Type 1
Gene Expression Regulation
Genotype
Image Processing, Computer-Assisted
In Situ Hybridization
Interleukin-12
Islets of Langerhans

Source

Open in PubMed

Identifiers

PMID: 10630383
DOI: 10.1097/00006676-200001000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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NF-kappa B

Pancreas

Pancreatitis

Prediabetic State