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Article

Contribution of programmed cell death receptor (PD)-1 to Kupffer cell dysfunction in murine polymicrobial sepsis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Aug 2016

Wang Fei, Huang Xin, Chung Chun-Shiang, Chen Yaping, Hutchins Noelle A, Ayala Alfred

Abstract excerpt

Recent studies suggest that coinhibitory receptors appear to be important in contributing sepsis-induced immunosuppression. Our laboratory reported that mice deficient in programmed cell death receptor (PD)-1 have increased bacterial clearance and improved survival in experimental sepsis induced by cecal ligation and puncture (CLP). In response to infection, the liver clears the blood of bacteria and produces...

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Identifiers

PMID: 27288425
DOI: 10.1152/ajpgi.00371.2015
PMCID: PMC5007287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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