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Article

Targeting Complement C5a Receptor 1 for the Treatment of Immunosuppression in Sepsis.

Molecular therapy : the journal of the American Society of Gene Therapy - 6 Jan 2021

Sommerfeld Oliver, Medyukhina Anna, Neugebauer Sophie, Ghait Mohamed, Ulferts Svenja, Lupp Amelie, König Rainer, Wetzker Reinhard, Schulz Stefan, Figge Marc Thilo, Bauer Michael, Press Adrian T

Abstract excerpt

Complement factor C5a was originally identified as a powerful promoter of inflammation through activation of the C5a receptor 1 (C5ar1). Recent evidence suggests involvement of C5a not only in pro- but also in anti-inflammatory signaling. The present study aims to unveil the role of C5ar1 as potential therapeutic target in a murine sepsis model. Our study discloses a significantly increased survival in models of...

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Identifiers

PMID: 32966769
DOI: 10.1016/j.ymthe.2020.09.008
PMCID: PMC7791006

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