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Article

BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction.

Journal of leukocyte biology - 1 Sept 2012

Shubin Nicholas J, Chung Chun S, Heffernan Daithi S, Irwin Lydea R, Monaghan Sean F, Ayala Alfred

Abstract excerpt

A proper innate inflammatory response is essential for prevention of the systemic inflammation associated with sepsis. BTLA is an immune-regulatory receptor demonstrated to be expressed not only on adaptive immune populations and have potent inhibitory effects on CD4(+) T cells but is also expressed on innate cell populations (CD11c(+) and CD11b(+) cells) and has been shown to diminish pathogen clearance...

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Source

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Identifiers

PMID: 22459947
DOI: 10.1189/jlb.1211641
PMCID: PMC3427605

Genes

BTLA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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