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Article

CCR5 deficiency increased susceptibility to lipopolysaccharide-induced acute renal injury.

Archives of toxicology - 1 May 2016

Lee Dong Hun, Park Mi Hee, Hwang Chul Ju, Hwang Jae Yeon, Yoon Hae Suk, Yoon Do Young, Hong Jin Tae

Abstract excerpt

C-C chemokine receptor 5 (CCR5) regulates leukocyte chemotaxis and activation, and its deficiency exacerbates development of nephritis. Therefore, we investigated the role of CCR5 during lipopolysaccharide (LPS)-induced acute kidney injury. CCR5-deficient (CCR5-/-) and wild-type (CCR5+/+) mice, both aged about 10 months, had acute renal injury induced by intraperitoneal injection of LPS (10 mg/kg). Compared with...

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Source

Identifiers

PMID: 26055553
DOI: 10.1007/s00204-015-1530-9

Genes

CCR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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