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Article

SPOTS: signaling protein oligomeric transduction structures are early mediators of death receptor-induced apoptosis at the plasma membrane.

The Journal of cell biology - 22 Nov 2004

Siegel Richard M, Muppidi Jagan R, Sarker Malabika, Lobito Adrian, Jen Melinda, Martin David, Straus Stephen E, Lenardo Michael J

Abstract excerpt

Fas (CD95, APO-1, TNFRSF6) is a TNF receptor superfamily member that directly triggers apoptosis and contributes to the maintenance of lymphocyte homeostasis and prevention of autoimmunity. Although FADD and caspase-8 have been identified as key intracellular mediators of Fas signaling, it is not clear how recruitment of these proteins to the Fas death domain leads to activation of caspase-8 in the receptor...

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Source

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Identifiers

PMID: 15557123
DOI: 10.1083/jcb.200406101
PMCID: PMC2172594

Genes

FADD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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