Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.

Science (New York, N.Y.) - 30 Jun 2000

Chan F K, Chun H J, Zheng L, Siegel R M, Bui K L, Lenardo M J

Abstract excerpt

A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor trimers. This pre-ligand-binding assembly domain (PLAD) is physically distinct from the domain that for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cross-Linking Reagents
Share to Energy Transfer
Share to Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macromolecular Substances

Share to Receptors, Tumor Necrosis Factor

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Receptors, Tumor Necrosis Factor, Type II

Share to Succinimides

Source

Identifiers

PMID: 10875917
DOI: 10.1126/science.288.5475.2351

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10875917-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.PMID 10875917Read ↗

Unraveling function in the TNF ligand and receptor families.Semantic proximity Read ↗

TNF-related ligands and their receptors.Semantic proximity Read ↗

The TNF receptor super family in immune regulationSemantic proximity Read ↗

The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the gamesSemantic proximity Read ↗

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells.Semantic proximity Read ↗

De novo masking domains that gate TNF-family ligand assembly and activitySemantic proximity Read ↗

Death Receptor Activation-Induced Hepatocyte Apoptosis and Liver InjurySemantic proximity Read ↗

Structural and biological features of the TNF receptor and TNF ligand superfamilies: Interactive signals in the pathobiology of Hodgkin's diseaseSemantic proximity Read ↗

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral ProteinsSemantic proximity Read ↗

Roles of the adaptor protein tumor necrosis factor receptor type 1-associated death domain protein (TRADD) in human diseasesSemantic proximity Read ↗

FADD self-association is required for stable interaction with an activated death receptor.Semantic proximity Read ↗

Signal transduction. FasL binds preassembled Fas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.