Article
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
Science (New York, N.Y.) - 30 Jun 2000
Chan F K, Chun H J, Zheng L, Siegel R M, Bui K L, Lenardo M J
Abstract excerpt
A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor trimers. This pre-ligand-binding assembly domain (PLAD) is physically distinct from the domain that forms the major contacts with ligand, but is necessary and sufficient for the assembly of TNFR complexes that bind...
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