Article

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and Activation

2023-07-20

Abstract excerpt

Efferocytosis – the phagocytic removal of apoptotic cells – is a central component of tissue homeostasis, and in many tissues is mediated by the efferocytic receptor MERTK expressed by macrophages. Although MERTK is critical for efferocytosis, the mechanism by which it directs the engulfment of apoptotic cells is largely unknown. Using immunoprecipitation, mass spectrometry, and super-resolution microscopy, we hav...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38a7e9d6-06fd-585d-898b-2bf683c297e2
DOI: 10.1101/2023.07.20.549870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MERTK Coordinates Efferocytosis by Regulating Integrin Localization and ActivationDOI 10.1101/2023.07.20.549870Read

TAM receptors in phagocytosis: Beyond the mere internalization of particlesSemantic proximity Read

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolutionSemantic proximity Read

TAM receptors in apoptotic cell clearance, autoimmunity, and cancerSemantic proximity Read

Efferocytosis Signaling in the Regulation of Macrophage Inflammatory ResponsesSemantic proximity Read

MERTK-Mediated LC3-Associated Phagocytosis (LAP) of Apoptotic Substrates in Blood-Separated Tissues: Retina, Testis, Ovarian FolliclesSemantic proximity Read

Evaluating the differential expression of TAM family receptors and efferocytosis activities in differentiated and polarized THP-1 macrophageSemantic proximity Read

Proteolysis of TAM receptors in autoimmune diseases and cancer: what does it say to us?Semantic proximity Read

Phagocytosis and clearance of apoptotic cells is mediated by MER.Semantic proximity Read

Efferocytosis and Its Role in Inflammatory DisordersSemantic proximity Read

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.Semantic proximity Read

The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An OverviewSemantic proximity Read

The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.Semantic proximity Read