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Article

Homotypic FADD interactions through a conserved RXDLL motif are required for death receptor-induced apoptosis.

Cell death and differentiation - 1 Oct 2006

Muppidi J R, Lobito A A, Ramaswamy M, Yang J K, Wang L, Wu H, Siegel R M

Abstract excerpt

Death receptors in the TNF receptor superfamily signal for apoptosis via the ordered recruitment of FADD and caspase-8 to a death-inducing signaling complex (DISC). However, the nature of the protein-protein interactions in the signaling complex is not well defined. Here we show that FADD self-associates through a conserved RXDLL motif in the death effector domain (DED). Despite exhibiting similar binding to both...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16410793
DOI: 10.1038/sj.cdd.4401855

Genes

FADD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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