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Article

Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.

Science (New York, N.Y.) - 30 Jun 2000

Siegel R M, Frederiksen J K, Zacharias D A, Chan F K, Johnson M, Lynch D, Tsien R Y, Lenardo M J

Abstract excerpt

Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative syndrome. This effect, rather than depending on ligand-induced receptor oligomerization, was found to stem from ligand- indep...

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Identifiers

PMID: 10875918
DOI: 10.1126/science.288.5475.2354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10875918-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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