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Article

The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations.

Nature structural & molecular biology - 1 Nov 2010

Wang Liwei, Yang Jin Kuk, Kabaleeswaran Venkataraman, Rice Amanda J, Cruz Anthony C, Park Ah Young, Yin Qian, Damko Ermelinda, Jang Se Bok, Raunser Stefan, Robinson Carol V, Siegel Richard M, Walz Thomas, Wu Hao

Abstract excerpt

The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor protein FADD and caspase-8 mediates the extrinsic apoptotic program. Mutations in Fas that disrupt the DISC cause autoimmune lymphoproliferative syndrome (ALPS). Here we show that the Fas-FADD death domain (...

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Source

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Identifiers

PMID: 20935634
DOI: 10.1038/nsmb.1920
PMCID: PMC2988912

Genes

FADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20935634-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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