Article
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity.
Nature immunology - 1 Dec 2000
Siegel R M, Chan F K, Chun H J, Lenardo M J
Abstract excerpt
Originally identified as a cell surface receptor that triggered the death of lymphocytes and tumor cells, it is now recognized that Fas (also known as CD95 or Apo-I) has distinct functions in the life and death of different cell types in the immune system. Fas signaling may also be involved in T cell costimulation and proliferation. Although Fas deficiency in humans and mice predisposes them towards systemic...
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