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Article

Craniofacial development in the talpid3 chicken mutant.

Differentiation; research in biological diversity - 1 Sept 2004

Buxton Paul, Davey Megan G, Paton I Robert, Morrice David R, Francis-West Philippa H, Burt David W, Tickle Cheryll

Abstract excerpt

The talpid(3) chicken mutant has a pleiotropic phenotype including polydactyly and craniofacial abnormalities. Limb polydactyly in talpid(3) suggests a gain of Hedgehog (Hh) signaling, whereas, paradoxically, absence of midline facial structures suggests a loss of Hh function. Here we analyze the status of Shh signaling in the talpid(3) mutant head. We show that Shh expression domains are lost from the talpid(3)...

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Identifiers

PMID: 15554946
DOI: 10.1111/j.1432-0436.2004.07207006.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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