Article
The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2.
Development (Cambridge, England) - 1 Aug 2014
Chang Ching-Fang, Schock Elizabeth N, O'Hare Elizabeth A, Dodgson Jerry, Cheng Hans H, Muir William M, Edelmann Richard E, Delany Mary E, Brugmann Samantha A
Abstract excerpt
talpid(2) is an avian autosomal recessive mutant with a myriad of congenital malformations, including polydactyly and facial clefting. Although phenotypically similar to talpid(3), talpid(2) has a distinct facial phenotype and an unknown cellular, molecular and genetic basis. We set out to determine the etiology of the craniofacial phenotype of this mutant. We confirmed that primary cilia were disrupted in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.