Article
Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant.
Developmental biology - 1 Dec 2005
Agarwala Seema, Aglyamova Galina V, Marma Amanda K, Fallon John F, Ragsdale Clifton W
Abstract excerpt
The chick talpid2 mutant displays polydactylous digits attributed to defects of the Hedgehog (HH) signaling pathway. We examined the talpid2 neural tube and show that patterning defects in the spinal cord and the midbrain are distinct from each other and from the limb. Unlike the Sonic Hedgehog (SHH) source in the limb, the SHH-rich floor plate (FP) is reduced in the talpid2 midbrain. This is accompanied by a...
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