Article
The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity.
Development (Cambridge, England) - 1 Apr 1992
Izpisúa-Belmonte J C, Ede D A, Tickle C, Duboule D
Abstract excerpt
Developing chicken wings homozygous for the talpid (ta3/ta3) mutation are polydactylous and have defects in the establishment of their anteroposterior polarity. We analysed the expression domains of the posteriorly restricted homeobox Hox-4 genes in such mutant wings. The Hox-4 genes are now expressed right across the anteroposterior axis instead of being expressed just posteriorly. This correlates well with the...
Topics
- Animals
- Chick Embryo
- Gene Expression
- Genes, Homeobox
- Homozygote
- Molecular Probe Techniques
- Morphogenesis
- Mutation
- Wings, Animal