Article

TALPID3/KIAA0586 regulates multiple aspects of neuromuscular patterning during gastrointestinal development in animal models and human

2021-05-29

Abstract excerpt

<h4>ABSTRACT</h4> TALPID3/KIAA0586 is an evolutionary conserved protein, which plays an essential role in protein trafficking. Its role during gastrointestinal (GI) and enteric nervous system (ENS) development has not been studied previously. Here, we analysed chicken, mouse and human embryonic GI tissues with TALPID3 mutations. The GI tract of TALPID3 chicken embryos was shortened and malformed. Histologically,...

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Literature Corpus work: 6573765f-3f68-5cc1-b8fe-e4d438ee4361
DOI: 10.1101/2021.05.28.446103

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