Article
Shh, HoxD, Bmp-2, and Fgf-4 gene expression during development of the polydactylous talpid2, diplopodia1, and diplopodia4 mutant chick limb buds.
Developmental genetics - 1 Jan 1996
Rodriguez C, Kos R, Macias D, Abbott U K, Izpisúa Belmonte J C
Abstract excerpt
Several polydactylous mutants affect the pattern of asymmetry along the anteroposterior axis of the vertebrate limb. In talpid2, diplopodia1, and diplopodia4 chick limb mutants, there is a preaxial extension that results in broader limb buds. Talpid2 shows reduction of the long bones and 9-10 syn...
Topics
- Animals
- Bone Morphogenetic Proteins
- Chick Embryo
- Fibroblast Growth Factor 4
- Fibroblast Growth Factors
- Gene Expression Regulation, Developmental
- Hedgehog Proteins
- Homeodomain Proteins
- Limb Buds
- Mutation
- Polydactyly
- Protein Biosynthesis
- Proto-Oncogene Proteins
- Reference Values
- Trans-Activators