Article
Expression of ptc and gli genes in talpid3 suggests bifurcation in Shh pathway.
Development (Cambridge, England) - 1 Jun 1999
Lewis K E, Drossopoulou G, Paton I R, Morrice D R, Robertson K E, Burt D W, Ingham P W, Tickle C
Abstract excerpt
talpid3 is an embryonic-lethal chicken mutation in a molecularly un-characterised autosomal gene. The recessive, pleiotropic phenotype includes polydactylous limbs with morphologically similar digits. Previous analysis established that hox-D and bmp genes, that are normally expressed posteriorly in the limb bud in response to a localised, posterior source of Sonic Hedgehog (Shh) are expressed symmetrically across...
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