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Article

A targeted mutation of Nkd1 impairs mouse spermatogenesis.

The Journal of biological chemistry - 28 Jan 2005

Li Qin, Ishikawa Tomo-O, Miyoshi Hiroyuki, Oshima Masanobu, Taketo Makoto M

Abstract excerpt

Nkd1 is an antagonist of the canonical Wnt/beta-catenin signaling pathway. The EF-hand motif of Nkd1 is required for its inhibitory function. Early studies suggested that Nkd1 might play important roles in mouse embryonic development and tumorigenesis. We constructed Nkd1(-/-) mice whose Nkd1 protein lacked the EF-hand and was unable to inhibit Wnt/beta-catenin signaling. The homozygotes were viable and grew...

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Source

Identifiers

PMID: 15546883
DOI: 10.1074/jbc.M405680200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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