Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development.

BMC genetics - 12 Dec 2012

Lossie Amy C, Lo Chiao-Ling, Baumgarner Katherine M, Cramer Melissa J, Garner Joseph P, Justice Monica J

Abstract excerpt

BACKGROUND: Our interests lie in determining the genes and genetic pathways that are important for establishing and maintaining maternal-fetal interactions during pregnancy. Mutation analysis targeted to a 34 Mb domain flanked by Trp53 and Wnt3 demonstrates that this region of mouse chromosome 11 contains a large number of essential genes. Two mutant alleles (l11Jus1 and l11Jus4), which fall into the same...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p21
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylnitrosourea

Share to Gene Expression Regulation, Developmental

Share to Microfilament Proteins

Share to Mutagenesis

Share to Pregnancy, Animal

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 23231322
DOI: 10.1186/1471-2156-13-106
PMCID: PMC3558363

Genes

NLE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development.PMID 23231322Read ↗

Notchless is required for axial skeleton formation in mice.Semantic proximity Read ↗

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defectsSemantic proximity Read ↗

An ENU-mutagenesis screen in the mouse: identification of novel developmental gene functions.Semantic proximity Read ↗

The orphan steroid receptor Nur77 family member Nor-1 is essential for early mouse embryogenesis.Semantic proximity Read ↗

Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling.Semantic proximity Read ↗

Temporal misexpression of <i>En1</i> during limb development causes distinct phenotypesSemantic proximity Read ↗

Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.Semantic proximity Read ↗

An obligatory role of mind bomb-1 in notch signaling of mammalian development.Semantic proximity Read ↗

Notch signaling in the mammalian central nervous system: insights from mouse mutants.Semantic proximity Read ↗

Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformationsSemantic proximity Read ↗

Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus.Semantic proximity Read ↗

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.