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Article

In Vivo Notch Signaling Blockade Induces Abnormal Spermatogenesis in the Mouse

20 Nov 2014

Abstract excerpt

In a previous study we identified active Notch signaling in key cellular events occurring at adult spermatogenesis. In this study, we evaluated the function of Notch signaling in spermatogenesis through the effects of in vivo Notch blockade. Adult CD1 male mice were either submitted to a long term DAPT (?-secretase inhibitor) or vehicle treatment. Treatment duration was designed to attain one half the time (25...

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PMID: 25412258
DOI: 10.1371/journal.pone.0113365

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