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Article

A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.

PloS one - 1 Jan 2015

Okuda Hidenobu, Kiuchi Hiroshi, Takao Tetsuya, Miyagawa Yasushi, Tsujimura Akira, Nonomura Norio, Miyata Haruhiko, Okabe Masaru, Ikawa Masahito, Kawakami Yoshitaka, Goshima Naoki, Wada Morimasa, Tanaka Hiromitsu

Abstract excerpt

Spermatogenesis is an elaborately regulated system dedicated to the continuous production of spermatozoa via the genesis of spermatogonia. In this process, a variety of genes are expressed that are relevant to the differentiation of germ cells at each stage. Although Notch signaling plays a critical role in germ cell development in Drosophila and Caenorhabditis elegans, its function and importance for...

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Identifiers

PMID: 25875095
DOI: 10.1371/journal.pone.0124293
PMCID: PMC4397068

Genes

HDAC3
NKAPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis.PMID 25875095Read ↗

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