Article
NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling.
Cellular signalling - 1 Feb 2015
Stancikova Jitka, Krausova Michaela, Kolar Michal, Fafilek Bohumil, Svec Jiri, Sedlacek Radislav, Neroldova Magdalena, Dobes Jan, Horazna Monika, Janeckova Lucie, Vojtechova Martina, Oliverius Martin, Jirsa Milan, Korinek Vladimir
Abstract excerpt
The activity of the Wnt pathway undergoes complex regulation to ensure proper functioning of this principal signaling mechanism during development of adult tissues. The regulation may occur at several levels and includes both positive and negative feedback loops. In the present study we employed one of such negative feedback regulators, naked cuticle homolog 1 (Nkd1), to follow the Wnt pathway activity in the...
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