Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Wnt1-Cre2 transgene is active in the male germline.

Genesis (New York, N.Y. : 2000) - 1 Mar 2022

Dinsmore Colin J, Ke Chen-Yeh, Soriano Philippe

Abstract excerpt

The Wnt1-Cre transgenic mouse line is widely used to express the CRE recombinase in neural crest lineages, but it overexpresses WNT1 itself, which can cause undesired phenotypes. To address this, we and others previously developed a Wnt1-Cre2 line based on the same regulatory elements as Wnt1-Cre but without ectopic Wnt1 expression. However, while Wnt1-Cre2 exhibits normal activity when transmitted from female...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Transgenes
Share to Germ Cells
Share to Integrases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Neural Crest

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 35180326
DOI: 10.1002/dvg.23468
PMCID: PMC8940701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Wnt1-Cre2 transgene is active in the male germline.PMID 35180326Read ↗

The Wnt1-Cre2 transgene causes aberrant recombination in non-neural crest cell typesSemantic proximity Read ↗

Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAsSemantic proximity Read ↗

Loss of Wnt5a Disrupts Primordial Germ Cell Migration and Male Sexual Development in Mice1Semantic proximity Read ↗

Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functionsSemantic proximity Read ↗

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CISSemantic proximity Read ↗

The functions of Wt1 in mouse gonad development and somatic cells differentiationSemantic proximity Read ↗

mRNA Expression Analysis and the Molecular Basis of Neonatal Testis Defects in <i>Dmrt1</i> Mutant MiceSemantic proximity Read ↗

Physiopathological aspects of the Wnt/β-catenin signaling pathway in the male reproductive systemSemantic proximity Read ↗

Cyp11a2 Is Essential for Oocyte Development and Spermatogonial Stem Cell Differentiation in Zebrafish.Semantic proximity Read ↗

Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic miceSemantic proximity Read ↗

Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse.Semantic proximity Read ↗

Generation of a mouse model for a conditional inactivation of Gtf2i allele.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.