Article
A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2004
Shi J, Misso N L, Duffy D L, Thompson P J, Kedda M-A
Abstract excerpt
BACKGROUND: Cyclooxygenase (COX)-2 is a key inducible enzyme that regulates the production of anti-inflammatory prostaglandin E(2). A single-nucleotide polymorphism, -765G>C, located within a stimulatory protein-1 binding site in the COX-2 promoter region, has been shown to have significantly lower promoter activity in vitro compared with the wild-type and was associated with decreased plasma levels of C-reactive...
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