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Article

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2002

Papafili Anastasia, Hill Michael R, Brull David J, McAnulty Robin J, Marshall Richard P, Humphries Steve E, Laurent Geoffrey J

Abstract excerpt

OBJECTIVE: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease. METHODS AND RESULTS: The promoter of COX-2 was screened for va...

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PMID: 12377741
DOI: 10.1161/01.atv.0000030340.80207.c5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12377741-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response.PMID 12377741Read ↗

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