Article
5' flanking region polymorphism of the gene encoding leukotriene C4 synthase does not correlate with the aspirin-intolerant asthma phenotype in the United States.
The Journal of allergy and clinical immunology - 1 Jul 2000
Van Sambeek R, Stevenson D D, Baldasaro M, Lam B K, Zhao J, Yoshida S, Yandora C, Drazen J M, Penrose J F
Abstract excerpt
BACKGROUND: Approximately 10% of patients with asthma have a distinct clinical entity in which their symptoms are exacerbated by aspirin and most other nonsteroidal anti-inflammatory agents. These individuals typically have significant basal overproduction of cysteinyl leukotrienes, and within their biosynthetic pathway, the terminal enzyme, leukotriene C(4) synthase (LTC(4)S), is significantly overexpressed. A...
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