Article
Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2008
Kim T-H, Chang H-S, Park S-M, Nam B-Y, Park J-S, Rhim T, Park H-S, Kim M-K, Choi I S, Cho S H, Chung I Y, Park B-L, Park C-S, Shin H-D
Abstract excerpt
BACKGROUND: Aspirin-intolerant asthma (AIA) refers to the development of bronchoconstriction in asthmatic individuals following the ingestion of aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). Angiotensin I-converting enzyme (ACE), a membrane-bound peptidase present in the lung, plays a pivotal role in the metabolism of the endogenous peptides involved in the pathogenesis of asthma. METHODS: We...
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