Article
Cyclooxygenase-2 gene polymorphisms in an Australian population: association of the -1195G > A promoter polymorphism with mild asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jun 2008
Shi J, Misso N L, Kedda M-A, Horn J, Welch M D, Duffy D L, Williams C, Thompson P J
Abstract excerpt
BACKGROUND: Cyclooxygenase (COX)-2 is an inducible enzyme responsible for catalysing the formation of prostaglandins (PGs) in settings of inflammation. Single nucleotide polymorphisms (SNPs) of the COX-2 gene may influence gene transcription and PG production in the asthmatic airway. OBJECTIVE: To evaluate the frequencies of COX-2 SNPs in an Australian Caucasian population, and determine potential associations...
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