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Article

Characterization of two polymorphisms in the leukotriene C4 synthase gene in an Australian population of subjects with mild, moderate, and severe asthma.

The Journal of allergy and clinical immunology - 1 May 2004

Kedda Mary-Anne, Shi Jing, Duffy David, Phelps Stephanie, Yang Ian, O'Hara Kirrily, Fong Kwun, Thompson Philip J

Abstract excerpt

BACKGROUND: The cysteinyl-leukotrienes (cys-LTs) are proinflammatory mediators that are important in the pathophysiology of asthma. LTC(4) synthase is a key enzyme in the cys-LT biosynthetic pathway, and studies in small populations have suggested that a promoter polymorphism (A(-444)C) in the gene might be associated with asthma severity and aspirin intolerance. OBJECTIVE: We sought to screen the LTC(4) synthase...

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Source

Identifiers

PMID: 15131571
DOI: 10.1016/j.jaci.2004.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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