Article
Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity.
Pharmacogenetics and genomics - 1 Dec 2010
Kim Byung Soo, Park Se-Min, Uhm Tae Gi, Kang Jin Hyun, Park Jong-Sook, Jang An-Soo, Uh Soo-Taek, Kim Mi-Kyeong, Choi Inseon S, Cho Sang Heon, Hong Cheon-Soo, Lee Yong Won, Lee Jae-Young, Choi Byoung Whui, Park Hae-Sim, Park Byung Lae, Shin Hyoung Doo, Chung Il Yup, Park Choon-Sik
Abstract excerpt
OBJECTIVE: Aspirin affects interleukin-4 (IL-4) synthesis; however, the genetic role of IL-4 has not been evaluated in asthmatics with aspirin hypersensitivity. The objective of the study was to examine the influence of single nucleotide polymorphisms (SNPs) in IL-4 gene on aspirin hypersensitivity in asthmatics at the genetic and molecular levels. METHODS: Aspirin-intolerant (AIA, n=103) and aspirin-tolerant...
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