Transforming c-Ki-ras mutation is a preneoplastic event in mouse mammary carcinogenesis induced in vitro by N-methyl-N-nitrosourea.

doi:10.1128/mcb.10.4.1593-1599.1990

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Article

Transforming c-Ki-ras mutation is a preneoplastic event in mouse mammary carcinogenesis induced in vitro by N-methyl-N-nitrosourea.

Molecular and cellular biology - 1 Apr 1990

Miyamoto S, Sukumar S, Guzman R C, Osborn R C, Nandi S

Abstract excerpt

Mouse mammary epithelial cells can be transformed in primary cultures to preneoplastic and neoplastic states when treated with N-methyl-N-nitrosourea (MNU). Mammary carcinomas arising from MNU-induced hyperplastic alveolar nodules (a type of mouse mammary preneoplastic lesion) contained transforming c-Ki-ras genes when examined by the NIH 3T3 focus assay. Hybridization of allele-specific oligonucleotides to...

Topics

Animals
Base Sequence
Blotting, Southern
Cell Transformation, Neoplastic
Cells, Cultured
DNA Probes
Female
Genes, ras
Mammary Neoplasms, Experimental
Methylnitrosourea
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Inbred Strains

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Polymerase Chain Reaction

Precancerous Conditions

Source

Open in PubMed Open full text

Identifiers

PMID: 2181280
DOI: 10.1128/mcb.10.4.1593-1599.1990
PMCID: PMC362264

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2181280-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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