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Article

Transforming c-Ki-ras mutation is a preneoplastic event in mouse mammary carcinogenesis induced in vitro by N-methyl-N-nitrosourea.

Molecular and cellular biology - 1 Apr 1990

Miyamoto S, Sukumar S, Guzman R C, Osborn R C, Nandi S

Abstract excerpt

Mouse mammary epithelial cells can be transformed in primary cultures to preneoplastic and neoplastic states when treated with N-methyl-N-nitrosourea (MNU). Mammary carcinomas arising from MNU-induced hyperplastic alveolar nodules (a type of mouse mammary preneoplastic lesion) contained transforming c-Ki-ras genes when examined by the NIH 3T3 focus assay. Hybridization of allele-specific oligonucleotides to...

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Identifiers

PMID: 2181280
DOI: 10.1128/mcb.10.4.1593-1599.1990
PMCID: PMC362264

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