Article
Two-Stage sampling designs for gene association studies.
Genetic epidemiology - 1 Dec 2004
Thomas Duncan, Xie Rongrong, Gebregziabher Mulugeta
Abstract excerpt
We consider two-stage case-control designs for testing associations between single nucleotide polymorphisms (SNPs) and disease, in which a subsample of subjects is used to select a panel of "tagging" SNPs that will be considered in the main study. We propose a pseudolikelihood [Pepe and Flemming, 1991: JASA 86:108-113] that combines the information from both the main study and the substudy to test the association...
Topics
- Case-Control Studies
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genetics, Population
- Genome, Human
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide