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Article

Optimal DNA pooling-based two-stage designs in case-control association studies.

Human heredity - 1 Jan 2009

Zhao Yihong, Wang Shuang

Abstract excerpt

Study cost remains the major limiting factor for genome-wide association studies due to the necessity of genotyping a large number of SNPs for a large number of subjects. Both DNA pooling strategies and two-stage designs have been proposed to reduce genotyping costs. In this study, we propose a cost-effective, two-stage approach with a DNA pooling strategy. During stage I, all markers are evaluated on a subset of...

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Identifiers

PMID: 18931509
DOI: 10.1159/000164398
PMCID: PMC2868915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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