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Article

Optimal designs for two-stage genome-wide association studies.

Genetic epidemiology - 1 Nov 2007

Skol Andrew D, Scott Laura J, Abecasis Gonçalo R, Boehnke Michael

Abstract excerpt

Genome-wide association (GWA) studies require genotyping hundreds of thousands of markers on thousands of subjects, and are expensive at current genotyping costs. To conserve resources, many GWA studies are adopting a staged design in which a proportion of the available samples are genotyped on all markers in stage 1, and a proportion of these markers are genotyped on the remaining samples in stage 2. We describe...

Topics

False Positive Reactions
Genetic Markers
Genome, Human
Genotype
Humans
Models, Genetic
Sequence Analysis, DNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17549752
DOI: 10.1002/gepi.20240

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