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Article

Optimal two-stage genotyping in population-based association studies.

Genetic epidemiology - 1 Sept 2003

Satagopan Jaya M, Elston Robert C

Abstract excerpt

We propose a cost-effective two-stage approach to investigate gene-disease associations when testing a large number of candidate markers using a case-control design. Under this approach, all the markers are genotyped and tested at stage 1 using a subset of affected cases and unaffected controls, and the most promising markers are genotyped on the remaining individuals and tested using all the individuals at stage...

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Identifiers

PMID: 12916023
DOI: 10.1002/gepi.10260
PMCID: PMC8978311

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Source receipt: pubmed, retrieved 7 Sept 2026.

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