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Article

Two-phase sample selection strategies for design and analysis in post-genome-wide association fine-mapping studies.

Statistics in medicine - 30 Dec 2021

Espin-Garcia Osvaldo, Craiu Radu V, Bull Shelley B

Abstract excerpt

Post-GWAS analysis, in many cases, focuses on fine-mapping targeted genetic regions discovered at GWAS-stage; that is, the aim is to pinpoint potential causal variants and susceptibility genes for complex traits and disease outcomes using next-generation sequencing (NGS) technologies. Large-scale GWAS cohorts are necessary to identify target regions given the typically modest genetic effect sizes. In this...

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PMID: 34596256
DOI: 10.1002/sim.9211
PMCID: PMC9293221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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