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Article

Probability that a two-stage genome-wide association study will detect a disease-associated snp and implications for multistage designs.

Annals of human genetics - 1 Nov 2008

Gail M H, Pfeiffer R M, Wheeler W, Pee D

Abstract excerpt

Large two-stage genome-wide association studies (GWASs) have been shown to reduce required genotyping with little loss of power, compared to a one-stage design, provided a substantial fraction of cases and controls, pi(sample), is included in stage 1. However, a number of recent GWASs have used pi(sample) < 0.2. Moreover, standard power calculations are not applicable because SNPs are selected in stage 1 by...

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Identifiers

PMID: 18652601
DOI: 10.1111/j.1469-1809.2008.00467.x
PMCID: PMC2574571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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