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Article

Two-stage designs for gene-disease association studies.

Biometrics - 1 Mar 2002

Satagopan Jaya M, Verbel David A, Venkatraman E S, Offit Kenneth E, Begg Colin B

Abstract excerpt

The goal of this article is to describe a two-stage design that maximizes the power to detect gene-disease associations when the principal design constraint is the total cost, represented by the total number of gene evaluations rather than the total number of individuals. In the first stage, all genes of interest are evaluated on a subset of individuals. The most promising genes are then evaluated on additional...

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Identifiers

PMID: 11890312
DOI: 10.1111/j.0006-341x.2002.00163.x
PMCID: PMC8978151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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