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Article

Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing.

Molecular and cellular biology - 1 Dec 2004

Silverman Edward J, Maeda Ayaka, Wei Janet, Smith Paul, Beggs Jean D, Lin Ren-Jang

Abstract excerpt

Prp2 is an RNA-dependent ATPase that activates the spliceosome before the first transesterification reaction of pre-mRNA splicing. Prp2 has extensive homology throughout the helicase domain characteristic of DEXD/H-box helicases and a conserved carboxyl-terminal domain also found in the spliceosomal helicases Prp16, Prp22, and Prp43. Despite the extensive homology shared by these helicases, each has a distinct,...

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Source

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Identifiers

PMID: 15542821
DOI: 10.1128/MCB.24.23.10101-10110.2004
PMCID: PMC529041

Genes

SPP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing.PMID 15542821Read ↗

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Semantic proximity Read ↗

Dominant negative mutants of the yeast splicing factor Prp2 map to a putative cleft region in the helicase domain of DExD/H-box proteins.Semantic proximity Read ↗

The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.Semantic proximity Read ↗

RNA helicase dynamics in pre-mRNA splicing.Semantic proximity Read ↗

Motifs IV and V in the DEAH box splicing factor Prp22 are important for RNA unwinding, and helicase-defective Prp22 mutants are suppressed by Prp8.Semantic proximity Read ↗

The final stages of spliceosome maturation require Spp2p that can interact with the DEAH box protein Prp2p and promote step 1 of splicing.Semantic proximity Read ↗

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.Semantic proximity Read ↗

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.Semantic proximity Read ↗

A dominant negative mutation in the conserved RNA helicase motif 'SAT' causes splicing factor PRP2 to stall in spliceosomes.Semantic proximity Read ↗

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.Semantic proximity Read ↗

Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency.Semantic proximity Read ↗

Activation of Prp28 ATPase by phosphorylated Npl3 at a critical step of spliceosome remodeling.Semantic proximity Read ↗

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