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Article

The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.

RNA (New York, N.Y.) - 1 Mar 2014

Wlodaver Alissa M, Staley Jonathan P

Abstract excerpt

After undergoing massive RNA and protein rearrangements during assembly, the spliceosome undergoes a final, more subtle, ATP-dependent rearrangement that is essential for catalysis. This rearrangement requires the DEAH-box protein Prp2p, an RNA-dependent ATPase. Prp2p has been implicated in destabilizing interactions between the spliceosome and the protein complexes SF3 and RES, but a role for Prp2p in...

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Source

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Identifiers

PMID: 24442613
DOI: 10.1261/rna.042598.113
PMCID: PMC3923124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.PMID 24442613Read ↗

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