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Article

Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 2002

Kuhn Andreas N, Reichl Elizabeth M, Brow David A

Abstract excerpt

Prp8 is the largest and most highly conserved protein in the spliceosome yet its mechanism of function is poorly understood. Our previous studies implicate Prp8 in control of spliceosome activation for the first catalytic step of splicing, because substitutions in five distinct regions (a-e) of Prp8 suppress a cold-sensitive block to activation caused by a mutation in U4 RNA. Catalytic activation of the...

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Identifiers

PMID: 12087126
DOI: 10.1073/pnas.102304299
PMCID: PMC123108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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