A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.

doi:10.1101/gad.5.4.629

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Article

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.

Genes & development - 1 Apr 1991

Strauss E J, Guthrie C

Abstract excerpt

We have isolated a cold-sensitive mutant of Saccharomyces cerevisiae in which the first step of mRNA splicing is inhibited. The growth and splicing defects are recessive and cosegregate, thus defining a single essential gene (PRP28). The wild-type PRP28 gene was cloned, and sequence analysis reveals extensive homology to a family of proteins that are thought to function as ATP-dependent RNA helicases. The cold...

Topics

Amino Acid Sequence
Cold Temperature
Crosses, Genetic
Exons
Genes, Fungal
Genes, Suppressor
Kinetics
Models, Genetic
Molecular Sequence Data
Multigene Family
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Helicases

RNA Nucleotidyltransferases

RNA Splicing

RNA, Messenger

Saccharomyces cerevisiae

Sequence Homology, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 2010088
DOI: 10.1101/gad.5.4.629

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2010088-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.PMID 2010088Read ↗

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