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Article

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.

Nucleic acids research - 16 Dec 2014

Cordin Olivier, Hahn Daniela, Alexander Ross, Gautam Amit, Saveanu Cosmin, Barrass J David, Beggs Jean D

Abstract excerpt

RNA helicases are essential for virtually all cellular processes, however, their regulation is poorly understood. The activities of eight RNA helicases are required for pre-mRNA splicing. Amongst these, Brr2p is unusual in having two helicase modules, of which only the amino-terminal helicase domain appears to be catalytically active. Using genetic and biochemical approaches, we investigated interaction of the...

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Identifiers

PMID: 25428373
DOI: 10.1093/nar/gku1238
PMCID: PMC4267655

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Source receipt: pubmed, retrieved 7 Sept 2026.

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