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Article

RNA helicase dynamics in pre-mRNA splicing.

The EMBO journal - 1 Dec 2000

Schwer B, Meszaros T

Abstract excerpt

The DExH-box NTPase/helicase Prp22p plays two important roles in pre-mRNA splicing. It promotes the second transesterification reaction and then catalyzes the ATP-dependent release of mature mRNA from the spliceosome. Evidence that helicase activity is important emerged from the analysis of Prp22p motif III (SAT) mutations that uncouple the NTPase and helicase activities. We find that S635A and T637A hydrolyse...

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Identifiers

PMID: 11101530
DOI: 10.1093/emboj/19.23.6582
PMCID: PMC305851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNA helicase dynamics in pre-mRNA splicing.PMID 11101530Read ↗

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