Article
The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.
The EMBO journal - 15 May 1998
Wagner J D, Jankowsky E, Company M, Pyle A M, Abelson J N
Abstract excerpt
Of the proteins required for pre-mRNA splicing, at least four, the DEAH-box proteins, are closely related due to the presence of a central 'RNA helicase-like' region, and extended homology through a large portion of the protein. A major unresolved question is the function of these proteins. Indir...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- DEAD-box RNA Helicases
- Fungal Proteins
- Genetic Complementation Test
- Hydrolysis
- Mutation
- Phenotype
- RNA Helicases
- RNA Splicing
- RNA Splicing Factors
- RNA, Double-Stranded
- RNA, Messenger
- RNA, Small Nuclear
- Recombinant Fusion Proteins