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Article

The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis.

Bone - 1 Nov 2004

Nagahama K, Aoki K, Nonaka K, Saito H, Takahashi M, Varghese B J, Shimokawa H, Azuma M, Ohya K, Ohyama K

Abstract excerpt

Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), a member of the immunoglobulin (Ig) superfamily, negatively regulates T cell activation. The deficiency of CTLA-4 induces profound osteopenia with an increase in osteoclastogenesis, suggesting the important role of activated T...

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Identifiers

PMID: 15542030
DOI: 10.1016/j.bone.2004.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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